- DAY 1 : KUL Friday 13 October, 2023
- DAY 2 : ULB 10.11.2023
- DAY 3: Friday 8 December 2023, UZGent, Gent
- DAY 4: IPG 19.01.2024
- DAY 5: UCL 09.02.2024
- DAY 6: UA 15.03.2024
- DAY 7: ULg 26.04.2024
- DAY 8: VUB 17.05.2024
ADDITONAL WORK
FINAL EXAMINATION
- 07.06.2024
- 06.09.2024
Detailed information per course day will come available below
DAY 1 : KUL Friday 13 October, 2023
Aula Wolfspoort, KU Leuven Huis Bethlehem, Schapenstraat 34, Leuven
- 09:30-10.20 Human genome: gene structure and function Prof. Jeroen Breckpot (Slides)
- Gene structure and function
- Gene regulation and activity
- 10:20-11:25 Next Generation Sequencing Dr. Wouter Bossuyt (Slides)
- Different platforms
- Main applications
- Basics of sequencing
- 11:25-11:35 Coffee Break
- 11:35-12:30 Tools of human molecular genetics/Human Diversity Prof. Joris Vermeesch (Slides)
- Mutational analysis
- Diagnostic applications
- Human diversity
- 12:30-13:30 Lunch
- 13:30-15:25 Principles of cytogenomics Prof. Joris Vermeesch (Slides)
- Tools for the study of copy number variation
- Clinical consequences of copy number variation
- 15:25-15:35 Coffee Break
- 15:35-16:30 The human genome and the chromosomal basis of heredity Prof. Thierry Voet (Slides)
- Basic concepts
- Introduction: The chromosome
- The 3D nucleus
- Mitosis
- Meiosis
DAY 2 : ULB 10.11.2023
Building C, level 4, auditorium CA.121 (salle "Gillet") (Slides)
• 09:00-10:30 Patterns of Single Gene Inheritance (Ch.7, T&T)
• 10:30-11:00 Break
• 11:00-12:00 Lunch
• 12:00-13:30 Continued + mutations and polymorphisms (Ch.4)
• 13:30-14:00 coffee break
• 14:00-15:00 Genetic variation in populations (Ch.9)
• 15:00-15:30 coffee break
• 15:30-17:30 Epigenetics (Slides)
9:00-13:30 Patterns of single gene inheritance
(Marc Abramowicz)
Monofactorial genetic diseases. Penetrance, expressivity. Dominant, recessive, and X-linked inheritance, and why these models are approximations. Incidence and prevalence. Pseudoautosomal inheritance. Lyonisation (partly). Mitochondrial inheritance (partly). Anticipation. New mutations. Germ-line and soma. Somatic mosaics, germ-line mosaics. Pedigrees. Intrafamilial and interfamilial variation. Genetic background.
Consanguinity, chances of homozygosity by descent. Consanguinity as common traditional practice. Inbred communities. Pseudodominance. Founder effect, overdominance. Uniparental disomy.
Genetic variation in individuals and populations: mutation and polymorphism
(Marc Abramowicz)
The life and death of a highly penetrant mutation (hemophilia). Wild type alleles, mutated alleles. The concept of neutral polymorphisms and minor mutations. Blood groups as an example of polymorphism. SNPs. CNVs. Hardy-Weinberg equilibrium, and factors that disturb it. Metapopulation. Mutations and diversity by change. Meiosis and diversity by assembly. Biological fitness. Positive and negative selection. Divergence and diversity.
The history of DF508. Most recent common ancestors. Coalescence. A schematic overview of the ascent of man. Gene tree, species tree. Trans-species polymorphisms. The "common disease, common variant" hypothesis. Haplotype blocks. HapMap. Effective population size. The special case of the Y chromosome.
Incidental findings.
Epigenetics (François Fuks)
1. Chromatin structure
1.a. Notions of chromatin structure.
1.b. Post-translational modifications of histones
1.c. DNA methylation: definition
1.d. Biological significations of epigenetics
2. Epigenetics : mechanistic insights
2.a. Crosstalks between histones modifications et DNA methylation:
the histone code hypothesis
2.b. Targeting and regulation of DNA methylation
3. Epigenetics and human diseases
3.a. DNA methylation and cancer
3.b. DNA methylation and neurodevelopmental syndromes (Rett and ICF)
3.c. Deacetylase and DNA methyltransferases inhibitors as anti-cancer epigenetic drugs
Last session = 16:30-17:30
DAY 3: Friday 8 December 2023, UZGent, Gent
UZ Campus, C. Heymanslaan 10, 9000 Ghent
Location: Entrance 32, AUD E, BLOK B
Part 1. The molecular, biochemical and cellular basis of genetic disease
- 09:30-10:20 Lessons from the hemoglobinopathies prof. dr. Bert Callewaert
- 10:20-11:10 Defects in receptor proteins and transport defects prof. dr. Olivier Vanakker (updated)
- 11:10-11:30 break
- 11:30-12:20 Disorders of structural proteins prof. dr. Sofie Symoens
- 12:20-13:30 lunch (sandwiches are provided)
- 13:30-14:20 Neurodegenerative disorders prof. dr. Bart Dermaut
Part 2. Human Gene Mapping and Disease Gene Identification
- 14:30-15:30 Gene Mapping and Disease Gene Identification prof. dr. Paul Coucke
- 15:30-15:45 break
- 15:45-17:00 Practical Session prof. dr. Paul Coucke
DAY 4: IPG 19.01.2024
09:30-11:00
Disorders of the autosomes (cytogenetics/molecular abnormalities and clinical aspects) (Chap. 6, part 1) Damien Lederer and Stéphanie Moortgat (Slides)
11:00-11:15 coffee break
11:15-12:45 Disorders of gonadal and sexual development (gonadal embryogenesis, cytogenetics/molecular abnormalities, and clinical aspects) (Chap. 6, part 2) Isabelle Maystadt (Slides)
12:45-13:30 lunch
13:30-15:00 Developmental Genetics and Birth defects (Chap. 14) Aude Tessier and Julie Desir (Slides)
15:00-15:30 coffee break
15:30-16:30
Treatments of metabolic diseases (Chap. 13, part 1) Dominique Roland (Slides)
19th January 2024 from 9h30 am to 4h30pm at the Institut de Pathologie et de Génétique (IPG) in Gosselies :
Location: 25 Avenue Georges Lemaître, 6041 Gosselies
Day 5: BeSHG Interuniversity Course in Genetics : UCL Day
Friday 9 February 2024
Auditoire central C, Avenue E. Mounier, 51, B-1200 Brussels
08.30-09.00 Registration
DEVELOPMENTAL GENETICS and BIRTH DEFECTS (relates to Thompson 8th ed chptr 14)
09.00-09.05 Introduction: Pr. Miikka Vikkula
09.05-09.50 Regulators of development: HOXs etc.: Pr. René Rezsohazy (Slides)
09.50-10.20 Birth defects: approach to syndromology: Pr. Yves Sznajer (Slides)
10.20-10.30 Q & A
10.30-10.50 Break
10.50-11.15 Cleft lip and palate: Pr. Nicole Revencu (Slides)
11.15-11.50 Vascular anomalies and overgrowth syndromes: Dr. Pascal Brouillard (Slides)
11.50-12.00 Q & A
CANCER GENETICS and GENOMICS (relates to Thompson 8th ed; chptr 15) Introduction to Cancer
12.00-12.05 Introduction: Pr. Miikka Vikkula
12.05-12.30 part 1 molecular basis and inherited cancers: Pr. Anne De Leener (Slides)
12.30-12.55 Hereditary basis of cancer – specifics for genetic counselling: Pr. Anne De Leener
12.55-13.00 Q & A
13.00-13.40 Lunch break
Hereditary cancers :
13.40-14.20 Inherited breast and ovarian cancer: Pr. François Duhoux (Slides)
14.20-14.35 part 2 colorectal cancer and others: Pr. Anne De Leener (Slides)
14.35-15.00 Inherited colon cancer: Pr. Anne De Leener
15.00-15.10 Q & A
15.10-15.30 Break
Acquired cancers
15.30-15.50 Paragangliomas and pheochromocytomas: Pr. Alexandre Persu (Slides)
15.50-16.10 Hematological malignancies: molecular pathogenesis of AML, as example: Pr. Violaine Havelange (Slides)
16.10-16.40 Biomarker-driven clinical trials: Dr. Rachel Galot (Slides)
16.40-17.00 Q & A
17.00 Closing
Prof Miikka VIKKULA, Human Genetics, de Duve Institute, UCLouvainContact via: clovis.lessuise@uclouvain.be; 02-764.74.94
Permanent education in Medical Genetics
15/03/2024
Day 6: Genetics of common disorders with complex inheritance (Thompson&Thomspon 9th edition chapter 9)
Program
8.45h registration and coffee (across the road in the Foyer, Q building)
9.15-10h Elementary concepts of multifactorial diseases Bettina Blaumeiser (Slides)
10-10.45h Concepts in complex genetics: from Fisher to GWAS Guy Van Camp (Slides)
10.45-11.30h Beyond GWAS Erik Fransen (Slides)
11.30-12h Osteoporosis as paradigm for studies into complex diseases Wim Van Hul (Slides)
12-13h lunch break (across the road in the Foyer, Q building)
13-14h Of mice and human genetics Frank Kooy (Slides)
14-16h Web resources and datamining in genetics Geert Vandeweyer,Wim Wuyts (Slides)
Location
UA Campus Drie Eiken, Universiteitsplein 1, 2610 Wilrijk (Antwerpen)
location on campus: building R (R 0.03)
map of the campus: Naar Campus Drie Eiken | Universiteit Antwerpen (uantwerpen.be)
DAY 7: ULg 26.04.2024
Pharmacogenetics and pharmacogenomics
Pharmacogenetics (Vincent Bours)
- metabolic enzymes and polymorphisms.
- Polymorphisms and drug transporters and targets.
- Genetic conditions generating unexpected side effects.
- Ethnic differences and clinical consequences.
Clinical aspects of dysmorphology (Saskia Bulk).
The immune system
Immune genetics (Stéphanie Humblet (KULeuven), Sabine Franke )
The HLA complex .
inherited immune defects.
Gene therapy in relation with immune defect.
acquired alterations of IGH and TCR loci in lymphoproliferative disorders.
Here is the program for the day:
09h-9h15: Welcome
9h15-10h15: S. HUMBLET: "Immune Genetics" (Slides)
10h15-10:30: Coffee break
10h30-11h30: V. BOURS: "Pharmacogenetics" (Slides) (Paper)
11h30-12h: S. BULK: "Clinical aspects of dysmorphology" (Slides)
12h-13h: Lunch
13h-14h00: S. BULK: "Clinical aspects of dysmorphology"
14h00-15h00: S. FRANKE: "Acquired alterations of IGH and TCR in lymphoproliferative disorders." (Slides)
It will take place in the auditorium Stainier, B36 CHU · Tour 4 : Pharmacie et Décanat de Médecine (uliege.be)
DAY 8: VUB 17.05.2024
Program:
- 09.00-10.00 Mt disorders and recurrence risk: Sara Seneca (Slides)
- 10.00-11.00 Recurrence risk in medical genetics Pieter Verdyck (Slides)
- 11.00-11.30 break
- 11.30-12..30 Prenatal diagnosis
- 12.30-13.30 break
- 13.30-14.30 Prenatal diagnosis (continued)
- 14.30-15.30 Preimplantation Genetic Test
- 15.30- 16.00 Psychological issues in reproductive genetics Julie Nekkebroeck (Slides)
Place to be: VUB, Campus Jette, Faculteit Geneeskunde & Farmacie
Laarbeeklaan 103
1090 Brussel
Auditorium Velkeniers
ADDITIONAL WORK
Students must contact the Program Organizing Committee (POC) member at the institution where they registered. Each student must produce a personal work on a genetic subject, under the supervision of a member of the Teaching College from his registration center. The contents should be equivalent to a publication in a peer-reviewed scientific journal as first author, or to a thorough review of a genetic topic presented to an interdisciplinary seminar. The additional must produce a written report. The additional work amounts to 2 ECTS.
FINAL EXAMINATION
07.06.2024
06.09.2024
More information will follow